General Cell Lines and Cell Cultures
Eurofins Discoverx ChemiScreen PAR2 Receptor Membrane Preparation, 1 vial. (HTS037M)
The ChemiScreen PAR2 Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of F2RL1 surface expression. ChemiScreen membrane preps can be used to screen for GPCR activity using GTPγS assays. Increased GPCR activation levels will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx Ready-to-Assay BB2 Bombesin Receptor Frozen Cells, 2 Vials of Cells. (HTS084RTA)
The Ready-to-Assay BB2 Bombesin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. bombesin) based activation of GRPR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses GRPR alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of GRPR, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen NK1 Tackykinin Receptor Stable Cell Line, 2 vials. (HTS080C)
The ChemiScreen NK1 Tachykinin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. tachykinins) based activation of TACR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses TACR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of TACR1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
ATCC Mycobacterium tuberculosis; variant bovis BCG
Mycobacterium tuberculosis variant bovis BCG strain TMC 1019 [BCG Japanese] was isolated from bovine milk. This bacterial culture has applications in agricultural research.
ATCC Candida tropicalis
An ampoule containing viable cells (may include yeast cells, pseudohyphae, true hyphae) suspended in cryoprotectant.
Eurofins Discoverx Ready-to-Assay GPR103/Peptide P518 Receptor Frozen Cells, 2 Vials of Cells. (HTS189RTA)
The Ready-to-Assay GPR103/Peptide P518 Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. QRFP neuropeptides) based activation of QRFPR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses QRFPR alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of QRFPR, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Innovative Research Inc Single Donor Human Synovial Fluid 1ml
Single Donor Human Synovial Fluid from Innovative Research is collected from rheumatoid arthritis patients. Samples are provided as non-pooled, single donor synovial fluid in 1ml aliquots.
Custom collections are available, so if you have any specific requests, please get in touch with our team! We are able to set up both prospective collections and pre-scheduled shipments that time out with your research project.
Synovial fluid, also referred to as synovia, reduces friction within synovial joints when they move. An ultrafiltrate from plasma, synovial fluid contains plasma proteins as well as proteins produced by joint tissue cells. Components of synovial fluid include hyaluronan and lubricin / PRG4. The main functions of synovial fluid include reducing friction, shock absorption, transporting nutrients and waste, and molecular sieving. Please note, the v
ATCC Moraxella; (Branhamella); catarrhalis
Quality control strain for IDS and Remel RapID NH products.
Eurofins Discoverx ChemiScreen Y4 Neuropeptide Y Receptor Stable Cell Line, 2 vials. (HTS204C)
The ChemiScreen Y4 Neuropeptide Y Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. peptide YY) based activation of NPY4R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses NPY4R alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of NPY4R, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.